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Omega 3 fatty acids: Preterm birth

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By: Sean Moloughney

Editor, Nutraceuticals World

Nutraceutical: Omega 3 fatty acids

Indication: Preterm birth

Source: Obstet Gynecol, February 2010; 115(2 Pt 1):234-42.

Research: Researchers conducted a randomized, double-masked, placebo-controlled trial in 13 centers. Women with a history of prior spontaneous singleton preterm birth and a current singleton gestation were assigned to either a daily omega 3 supplement (1200 mg EPA and 800 mg DHA) or matching placebo from 16-22 through 36 weeks of gestation. All participants received weekly intramuscular 17alpha-hydroxyprogesterone caproate (250 mg). The primary study outcome was delivery before 37 weeks of gestation.

Results: A total of 852 women were included, and none were lost to follow-up. Delivery before 37 weeks of gestation occurred in 38% (164/434) of women in the omega 3 group and 42% (174/418) in the placebo group. From these findings researchers concluded that omega 3 supplementation offered no benefit in reducing preterm birth among women receiving 17alpha-hydroxyprogesterone caproate who have a history of preterm delivery.

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